Webinar will be held on Wednesday, March 30, 2022, from 8:00 a.m. to 9:00 a.m. EDT
NEW HAVEN, Conn., Trevi Therapeutics, Inc. (Nasdaq: TRVI) is a clinical-stage biopharmaceutical company developing an investigational oral therapy Haduvio™ (nalbuphine ER). Today, Trevi announced that it will host a webinar featuring a key opinion leader (KOL) who will discuss the seriousness of chronic cough in idiopathic pulmonary fibrosis (IPF) patients, the current treatment landscape, and the unmet medical need in treating IPF patients with chronic cough. Dr. William Forbes, Trevi’s Chief Development Officer, will also provide a brief overview of the recent positive interim analysis results from the Phase 2 Cough And NALbuphine (CANAL) trial of Haduvio. A live question and answer session will follow the presentations. The webinar will take place on Wednesday, March 30, 2022, from 8:00 a.m. to 9:00 a.m. Eastern time.
Trevi to host a webinar on the seriousness of chronic cough in IPF & recent interim CANAL data March 30 at 8:00 a.m. EDT
IPF is a serious, end-of-life disease where cough is one of the most significant symptoms. There are estimated to be 130,000 IPF patients in the US and more than 1 million patients ex-US, where up to 85% of these patients experience chronic cough. There are no approved therapies for the treatment of chronic cough in IPF, and the cough is often refractory to antitussive therapy. Patients with chronic cough in IPF can cough up to 520 times per day, leading to increased feelings of anxiety as it induces breathlessness. Coughing spells or episodes lead to significant fatigue, air hunger, peripheral oxygen desaturation and some patients also experience cough-related urinary incontinence. The social impact of chronic cough in IPF further compounds limited exercise ability, reduced walking distance and the need to use supplemental oxygen. The chronic cough in IPF may be an early clinical marker of disease activity, identify patients at high risk of progression, predict time to death or lung transplant, and may also contribute to enhanced activation of profibrotic mechanisms and disease worsening in IPF.
Upcoming Meetings
The Company plans to present at the following upcoming conferences and events:
March 30, 8:00 a.m. – 9:00 a.m. ET: “Understanding the Seriousness of Chronic Cough in IPF Patients and Trevi’s Latest Data.” A webinar featuring Trevi management, along with insights from an IPF expert.April 12, 8:00 a.m. – 8:45 a.m. ET Fireside Chat: 21st Annual Needham Virtual Healthcare Conference
About CANAL
The Phase 2 Cough And NALbuphine (CANAL) trial is a double-blind, randomized, placebo-controlled, 2-treatment, 2-period crossover efficacy and safety study of nalbuphine ER for chronic cough in patients with IPF taking place in the United Kingdom. The study consists of 2 treatment periods of 3 weeks, with a washout period of 2 weeks after each treatment period. The primary efficacy endpoint is to evaluate the effect of nalbuphine ER tablets on the mean daytime cough frequency at day 22 compared to placebo as measured by an objective cough monitor. More information about the CANAL trial is available at www.clinicaltrials.gov: NCT04030026
About Trevi Therapeutics, Inc.
Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the development and commercialization of the investigational therapy Haduvio to treat serious neurologically mediated conditions. Trevi is conducting a Phase 2b/3 clinical trial of Haduvio for the treatment of chronic pruritus associated with prurigo nodularis (PN) and a Phase 2 trial for chronic cough in patients with idiopathic pulmonary fibrosis (IPF). These conditions share a common pathophysiology that is mediated through opioid receptors in the central and peripheral nervous systems.
Founded in 2011, Trevi Therapeutics is headquartered in New Haven, CT.
About Haduvio
Haduvio, an investigational therapy, is an oral extended-release (ER) formulation of nalbuphine. Nalbuphine is a mixed ĸ-opioid receptor agonist and µ-opioid receptor antagonist that has been approved and marketed as an injectable for pain indications for more than 20 years in the United States and Europe. The ĸ- and µ-opioid receptors are known to be critical mediators of itch, cough and certain movement disorders. Nalbuphine’s mechanism of action may also mitigate the risk of abuse associated with µ-opioid agonists because it antagonizes, or blocks, µ-opioid receptors. Parenteral nalbuphine is not currently classified as a controlled substance by the DEA in the United States or by regulatory authorities in most of Europe. Trevi intends to propose Haduvio as the trade name for nalbuphine ER. Nalbuphine ER (Haduvio) is an investigational therapy that has been granted Fast Track designation by the FDA for the proposed indication of reduction of moderate to severe pruritus in patients with prurigo nodularis. Its safety and efficacy have not been evaluated by any regulatory authority.
This article was shared with Prittle Prattle News as a Press Release.
