LA JOLLA, Calif., May 19, 2021 — Avidity Biosciences, Inc. (Nasdaq: RNA), a biopharmaceutical company pioneering a new class of oligonucleotide-based therapies called Antibody Oligonucleotide Conjugates (AOCs™), announced that new preclinical data on its lead AOC program, AOC 1001, and key programmatic updates will be shared at a virtual investor and analyst event today. The event at 8:00am PT is titled “Engineering AOCs” and is the first in a series of investor and analyst events that the company plans to host in 2021.
Avidity Pipeline Updates
- AOC 1001 for Myotonic Dystrophy Type 1 (DM1) demonstrates safety profile that supports advancement to clinic. During today’s virtual investor and analyst event, Avidity will share comprehensive results from its non-human primate (NHP) toxicology studies (both Good Laboratory Practice, or GLP, and non-GLP) that support the clinical evaluation of AOC 1001. Results from the AOC 1001 GLP toxicology study show a favorable safety profile that supports advancement into the clinic.
- AOC 1044 named as clinical development candidate for Duchenne Muscular Dystrophy (DMD) program targeting Exon 44. AOC 1044 is the first of three programs for DMD and is now entering IND-enabling studies. Avidity remains on track with plans to commence clinical trials for AOC 1044 and its AOC FSHD program for facioscapulohumeral muscular dystrophy (FSHD) in 2022, following additional preparatory preclinical studies and regulatory clearance.
“This event is the first in a series highlighting the great work being done by the team at Avidity. Our AOC platform is built upon years of engineering and rigorously following the data. It has the potential to revolutionize the delivery of oligonucleotide therapeutics to multiple cell and tissue types to profoundly impact the lives of people suffering from serious diseases. We look forward to sharing data today from our first AOC candidate, AOC 1001, which remains on track to enter the clinic in the second half of this year,” said Sarah Boyce, president and CEO of Avidity. “We are also grateful to have Dr. Zamore and Dr. Dowdy joining us for a panel discussion on the important role for RNA therapeutics in treating diseases that are currently underserved.”
About Avidity Biosciences
Avidity Biosciences, Inc. is driven to change lives with a new class of therapies called Antibody Oligonucleotide Conjugates (AOCs) that are designed to overcome current limitations of oligonucleotide therapies in order to treat a wide range of serious diseases. Avidity’s proprietary AOC platform combines the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide therapies to access previously undruggable tissue and cell types and more effectively target underlying genetic drivers of diseases. Avidity’s lead product candidate, AOC 1001, is designed to treat myotonic dystrophy type 1, and its other muscle programs are focused on the treatment of Duchenne muscular dystrophy, facioscapulohumeral muscular dystrophy, Pompe disease and muscle atrophy. In addition to its muscle franchise, Avidity has research efforts focused on immune cells, cardiac tissue and other cell types.
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